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Home >> Signaling Pathways >> Proteases >> Elastase

Elastase

Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.

Biochemicals

  1. Cat.No. Product Name Information
  2. A4432 ARP 100 Selective MMP-2 inhibitor
  3. B1037 Alvelestat NE inhibitor
  4. C4325 BAY-678 HNE inhibitor
  5. C3609 (Z-Ala-Ala-Ala-Ala)2Rh110 fluorogenic elastase substrate
  6. C3252 Neutrophil Elastase Inhibitor neutrophil elastase inhibitor
  7. B6189 Sivelestat (ONO-5046) neutrophil elastase inhibitor
  8. A4431 SSR 69071 HLE inhibitor
  9. A4430 Sivelestat sodium salt Leukocyte elastase inhibitor
  10. B4675 GW311616 inhibitor of human neutrophil elastase(HNE)
  11. B4676 GW311616 hydrochloride HNE inhibitor