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FAAH

Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A4361 JNJ-1661010 FAAH inhibitor,potent and selective
  3. B5714 SA 47 FAAH inhibitor
  4. B5704 SA 57 FAAH inhibitor
  5. B5562 TC-F 2 FAAH inhibitor
  6. B7701 JZL 195 Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
  7. B7356 PF 750 FAAH inhibitor
  8. A3714 PF-04457845 FAAH inhibitor,potent and exquisitely selective
  9. A3571 LY2183240 Blocker of anandamide uptake,highly potent
  10. A4372 URB597 FAAH inhibitor,potent and selective
  11. C5719 Oleyl Trifluoromethyl Ketone potent inhibitor of FAAH
  12. C5452 Monoacylglycerol Lipase Inhibitor 21 inhibitor of monoacylglycerol lipase (MAGL) and FAAH
  13. C5619 N-Benzylpalmitamide inhibitor of fatty acid amide hydrolase (FAAH)
  14. C5178 Methyl α-Linolenyl Fluorophosphonate inhibitor of phospholipases, FAAH
  15. C4983 JP83 irreversible fatty acyl amide hydrolase (FAAH) inhibitor
  16. C4756 PF-622 potent, time-dependent, irreversible FAAH inhibitor
  17. C4279 4-(n-nonyl) Benzeneboronic Acid FAAH and MAGL inhibitor
  18. C4251 Oleoyl Ethyl Amide FAAH inhibitor with potential analgesic and anxiolytic activity
  19. C4122 JNJ-42165279 FAAH inhibitor
  20. B4931 TAK 21d Potent FAAH inhibitor
  21. B1245 FAAH inhibitor 1 Potent fatty acid amide hydrolase (FAAH) inhibitor
  22. A4374 PF-3845 FAAH ihibitor,highly potent and selective