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Bromodomain

Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

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  1. Cat.No. Product Name Information
  2. A8181 (-)-JQ1 BET bromodomain inhibitor
  3. C3076 AZD 5153 orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4.
  4. B4915 BAZ2-ICR Selective BAZ2 bromodomain inhibitor
  5. B5887 BET bromodomain inhibitor Potent and selective inhibitor for BRD4
  6. B6196 BI-7273 BRD9 bromodomain inhibitor
  7. B6184 BI-9564 BRD9/7 specific inhibitor
  8. A1910 Bromodomain Inhibitor, (+)-JQ1 BET bromodomain inhibitor
  9. A4186 Bromosporine Bromodomain inhibitor,non-selective
  10. B1081 CPI-203 BET bromodomain inhibitor
  11. B7801 CPI-637 CBP/EP300 bromodomain inhibitor

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