Bromodomain
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
- Cat.No. Product Name Information
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A1910
Bromodomain Inhibitor, (+)-JQ1
(+)-JQ1 is a BET bromodomain inhibitor, inhibits binding of a tetraacetylated the bromodomain 1/2 of BRD4 with IC50 of 77 nM and 33 nM, respectively.
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C4229
UMB-32
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C4097
NI-57
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C3668
GSK6853
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C3076
AZD 5153
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B7801
CPI-637
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B6197
PF-CBP1
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B6196
BI-7273
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B6184
BI-9564
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B6169
I-BRD9