Search results for: 'GSK-3β'
Items 1-10 of 156
- GSK1324726ACatalog No. :B1013BET proteins inhibitorGSK1324726A is a selective small molecule inhibitor of BET proteins with IC50 values of 41nM, 31nM and 22nM, respectively for BRD2, BRD3 and BRD4 .
- Dabrafenib Mesylate (GSK-2118436)Catalog No. :A3347Inhibitor of BRAF(V600) mutantsGSK2118436 is a selective BRAF V600E inhibitor. BRAF encodes a proto-oncogene B-Raf also known as serine/threonine protein kinase B-Raf. It is critical in regulating the MAPK/ERK signaling pathway. BRAF mutations frequently occur in many human cancers. [1, 2] BRAF V600E mutant is constitutively active, allowing MAPK/ERK activation independent of upstream cues.
- GSK744 (S/GSK1265744)Catalog No. :A8566HIV integrase inhibitor, oral active and long-actingGSK744 (S/GSK1265744) is a potential inhibitor of HIV integrase with IC50 value of 3 nM.
- GSK2606414Catalog No. :A3448PERK inhibitor,potent and selective
GSK2606414 is a selective inhibitor of PERK with IC50 value of 0.4nM.
- GSK 525768ACatalog No. :A3445inactive stereoisomer of I-BET-762GSK 525768A is the inactive stereoisomer of I-BET-762 which is a selective inhibitor of BET family with IC50 value of 35 nM
- S/GSK1349572Catalog No. :A4074HIV integrase inhibitor, novel and potent
S/GSK1349572, also known as dolutegravir, is a novel and potent inhibitor of human immunodeficiency virus (HIV) integrase (IN) blocking the strand transfer of integration of the viral genome into the host cell’s DNA.
- Trametinib (GSK1120212)Catalog No. :A3018MEK1 and MEK2 inhibitor, potent and selective
Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.
- GSK1070916Catalog No. :A4127Aurora B/C inhibitorGSK1070916 is a potent and selective inhibitor of Aurora B/C Kinase with Ki values of 0.38nM and 1.5nM, respectively .
- GSK2838232Catalog No. :B5818HIV-1 maturation inhibitorGSK2838232 is an HIV-1 maturation inhibitor  .
- GSK2126458Catalog No. :A8556PI3K/mTOR inhibitor
GSK2126458 is an inhibitor of PI3K/mTOR with Ki value of 19 pM for PI3K .