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AL 34662

Catalog No.
C5271
potent 5-HT2 receptor agonist
Grouped product items
SizePriceStock Qty
10mg
$96.00
Ship with 5-10 days
50mg
$416.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

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Background

IC50: 0.8-1.5 nM for rat and human 5-HT2 receptor

AL 34662 is a potent 5-HT2 receptor agonist.

SEROTONIN (5-hydroxytryptamine; 5-HT) is a major neurotransmitter in the central nervous system (CNS) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs.

In vitro: AL-34662 exhibited a high affinity for the rat and human 5-HT2 receptor and for cloned human 5-HT2A-C receptors. AL-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. AL-34662 also mobilized intracellular Ca2+ in h-CM and h-TM cells, being a full agonist like 5-HT itself. AL-34662's effects in the h-CM cells were potently antagonized by 5-HT2A-antagonist M-100907, but weakly by 5-HT2B-antagonist, 5-HT2B/C- antagonist and 5-HT2C antagonist. Moreover, it was found that the (R)-enantiomer (AL-34707) and the racemate (AL-34497) were less potent and/or efficacious than AL-34662 in all of these assays [1].

In vivo: AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. It efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Sharif NA, McLaughlin MA, Kelly CR.  AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt191.2
Cas No.210580-75-9
FormulaC10H13N3O
SynonymsAL 34497
Solubility≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
Chemical Name1-[(2S)-2-aminopropyl]-1H-indazol-6-ol
SDFDownload SDF
Canonical SMILESOC1=CC=C(C=NN2C[[email protected]](N)C)C2=C1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

AL 34662