In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50: 0.8-1.5 nM for rat and human 5-HT2 receptor
AL 34662 is a potent 5-HT2 receptor agonist.
SEROTONIN (5-hydroxytryptamine; 5-HT) is a major neurotransmitter in the central nervous system (CNS) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs.
In vitro: AL-34662 exhibited a high affinity for the rat and human 5-HT2 receptor and for cloned human 5-HT2A-C receptors. AL-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. AL-34662 also mobilized intracellular Ca2+ in h-CM and h-TM cells, being a full agonist like 5-HT itself. AL-34662's effects in the h-CM cells were potently antagonized by 5-HT2A-antagonist M-100907, but weakly by 5-HT2B-antagonist, 5-HT2B/C- antagonist and 5-HT2C antagonist. Moreover, it was found that the (R)-enantiomer (AL-34707) and the racemate (AL-34497) were less potent and/or efficacious than AL-34662 in all of these assays .
In vivo: AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. It efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes .
Clinical trial: So far, no clinical study has been conducted.
 Sharif NA, McLaughlin MA, Kelly CR. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13.
|Physical Appearance||A crystalline solid|
|Storage||Store at -20°C|
|Solubility||≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide|
|Canonical SMILES||OC1=CC=C(C=NN2C[[email protected]](N)C)C2=C1|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|