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Beta-Secretase Activity Fluorometric Assay Kit

Catalog No.
K2043
Detects β-secretase activity, highly sensitive.
Grouped product items
SizePriceStock Qty
100 assays
$510.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

β-Secretase is an aspartic-acid protease that plays an important role in Alzheimer’s disease and has been an excellent target for the treatment of Alzheimer’s disease based on anti-amyloid therapy.

 The Beta-Secretase Activity Fluorometric Assay Kit provides a highly sensitive and convenient way for detection of β-secretase activity in various biological and purified samples based on fluorescence method. The assay utilizes a β-secretase-specific peptide substrate conjugated to two molecules EDANS and DABCYL. In the uncleaved form, the fluorescent emissions from EDANS are quenched by the DABCYL moiety because of the physical proximity. Upon cleavage by β-secretase, EDANS is physically separated with DABCYL, which allowing for the release of a fluorescent signal. The activity of β-secretase in samples is proportionally related to the level of fluorescence intensity.

Features & Properties

FeaturesFast and convenient Simple procedure; takes 1 hour. The assay is sensitive, stable and high-throughput adaptable.
ShippingGel pack
Storage ConditionsStore at -20°C.

Quality Control

Quality Control & DataSheet

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Related Biological Data

Beta-Secretase Activity Fluorometric Assay Kit

Related Biological Data

Beta-Secretase Activity Fluorometric Assay Kit

Related Biological Data

Beta-Secretase Activity Fluorometric Assay Kit
 

Overview

Kit componentsβ-Secretase Extraction Buffer β-Secretase Reaction Buffer (2X) β-Secretase Substrate (in DMSO) Active β-Secretase (Lyophilized) β-Secretase Inhibitor (in DMSO)