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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Oncostatin (OSM) is a pleiotropic cytokine produced by activated T cells, monocytes, and Kaposi’ s sarcoma cells. OSM stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, inhibits the growth of some normal and tumor cell lines, promotes cytokine release (IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.
Human OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature OSM protein. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 26 kDa protein containing 227 amino acid residues.