AICAR phosphate （Acadesine）is an activator of AMPK .
AICAR phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the EC50 value is 380±60μM on the viability assay of B-CLL cells. In addition, AICAR phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in B-CLL cells. Furthermore, AICAR phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate AMPK. Apart from these, AICAR phosphate (2-4 mM) has shown to only slightly affects the viability of T cells from B-CLL patients, AICAR phosphate (0.5 mM) has been noted to remarkedly reduces viability of B cells but not T cells .
 Campàs C1, Lopez JM, Santidrián AF, Barragán M, Bellosillo B, Colomer D, Gil J. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003 May 1;101(9):3674-80. Epub 2003 Jan 9.
|Storage||Store at -20°C|
|Solubility||Soluble in DMSO|
|Chemical Name||5-amino-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazole-4-carboxamide phosphate|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|