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ZM 449829JAK3 inhibitor

ZM 449829

Catalog No. A4517
Size Price Stock Qty
10mg $134.00 In stock
50mg $603.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

ZM 449829

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Chemical Properties

Cas No. 4452-06-6 SDF Download SDF
Chemical Name 1-(naphthalen-2-yl)prop-2-en-1-one
Canonical SMILES O=C(C=C)C1=CC2=C(C=C1)C=CC=C2
Formula C13H10O M.Wt 182.22
Solubility >8.2mg/mL in DMSO Storage Desiccate at -20°C
General tips N/A
Shipping Condition N/A

Background

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively.