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Vc-MMADPotent tubulin inhibitor

Vc-MMAD

Catalog No. A3910
Size Price Stock
5mg $931.00 Please Inquire
10mg $1,425.00 Please Inquire

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & MSDS

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Chemical structure

Vc-MMAD

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Chemical Properties

Cas No. 1401963-17-4 SDF Download SDF
Synonyms Vc MMAD;VcMMAD
Chemical Name (Z)-N-((S,Z)-1-(((S)-1-((4-((5S,8S,11S,12R,Z)-11-((S)-sec-butyl)-6-hydroxy-12-(2-((S)-2-((1R,2R,Z)-3-hydroxy-1-methoxy-2-methyl-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)imino)propyl)pyrrolidin-1-yl)-2-oxoethyl)-5,8-diisopropyl-4,10-dimethyl-3,9-dioxo-2,13-d
Canonical SMILES CC[C@]([C@@](N(C([C@](/N=C(O)/[C@](N(C(OCC1=CC=C(NC([C@](/N=C(O)/[C@](/N=C(O)/CCCCCN2C(C=CC2=O)=O)([H])C(C)C)([H])CCCNC(O)=N)=O)C=C1)=O)C)([H])C(C)C)([H])C(C)C)=O)C)([H])[C@@](OC)([H])CC(N3CCC[C@@]3([H])[C@@](OC)([H])[C@@](/C(O)=N/[C@@](C4=NC=CS4)([H])CC5
Formula C70H104N12O14S M.Wt 1369.71
Solubility Soluble in DMSO Storage Store at -20°C
General tips No
Shipping Condition No

Background

Description: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate. For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).