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Vc-MMAD

antibody drug conjugate.

Vc-MMAD

Catalog No. A3910
Size Price Stock Qty
5mg $931.00 Ship Within 7 Days
10mg $1,425.00 Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Vc-MMAD Dilution Calculator

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Chemical Properties

Cas No. 1401963-17-4 SDF
Synonyms Vc MMAD;VcMMAD
Formula C70H104N12O14S M.Wt 1369.71
Solubility Soluble in DMSO Storage Store at -20°C
Shipping Condition: Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Description: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate. For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).