• We specialize in small molecule inhibitors, agonists, antagonists and screening libraries!
Search Site
Related Products
UPF 1069Selective PARP2 inhibitor

UPF 1069

Catalog No. A4163
Size Price Stock Qty
10mM (in 1mL DMSO) $99.00 In stock
10mg $90.00 In stock
50mg $290.00 In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

UPF 1069

Biological Activity

UPF 1069 is a selective inhibitor of PARP2 with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.
Targets PARP2          
IC50 0.3 μM          

UPF 1069 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

UPF 1069 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. 1048371-03-4 SDF Download SDF
Synonyms UPF-1069,UPF1069
Chemical Name 5-phenacyloxy-2H-isoquinolin-1-one
Canonical SMILES C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O
Formula C17H13NO3 M.Wt 279.29
Solubility >12.7mg/mL in DMSO Storage Store at -20°C
General tips N/A
Shipping Condition N/A

Background

UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2), with the value of 50% inhibition concentration IC50 of 0.3 μmol/L, that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency (the value of IC50 of 8 μmol/L). Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.

Reference

Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009;157(5):854-862