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Tretinoin (Aberela)

Catalog No.
A8539
retinoic acid, treats acne vulgaris and keratosis pilaris
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$80.00
In stock
100mg
$53.00
In stock
500mg
$79.00
In stock
1g
$96.00
In stock
5g
$328.00
In stock

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Email: [email protected]

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Background

Tretinoin(Aberela) is retinoic acid in pharmaceutical form and used to treat acne vulgaris and keratosis pilaris.

In cultured human mesangial cells, tretinoin increased the reduced glutathione content and the catalase activity in a dose- and time-dependent way, which then prevented the cytotoxicity of H2O2 [1].

In old male Fischer 344 rats, tretinoin inhibited the expression of TNF-β1 and osteopontin (a protein with chemotactic and cell adhesive properties) in the renal cortex [1]. In male NMRI-mice treated with 1×109 sheep red blood cells (SRBCs), tretinoin markedly inhibited cellular immunity and increased humoral immunity. Tretinoin reduced lymphocyte proliferation, NBT reduction and the secretion of interleukin-17, but increased the production of interleukin-10 [2]. In patients with facial acne, clindamycin phosphate Tretinoin Gel (CTG) (1.2% clindamycin phosphate, 0.025% tretinoin in a gel base (Velac)) was significantly more effective than 0.025% tretinoin, which relayed on the anti-inflammatory efficacy of tretinoin [3].

References:
[1].  Manzano VM, Puyol MR, Puyol DR, et al. Tretinoin prevents age-related renal changes and stimulates antioxidant defenses in cultured renal mesangial cells. J Pharmacol Exp Ther, 1999, 289(1): 123-132.
[2].  Froushani SM, Galeh HE. New insight into the immunomodulatory mechanisms of Tretinoin in NMRI mice. Iran J Basic Med Sci, 2014, 17(9): 632-637.
[3].  Richter JR, Förström LR, Kiistala UO, et al. Efficacy of the fixed 1.2% clindamycin phosphate, 0.025% tretinoin gel formulation (Velac) and a proprietary 0.025% tretinoin gel formulation (Aberela) in the topical control of facial acne. J Eur Acad Dermatol Venereol, 1998, 11(3): 227-233.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt300.4
Cas No.302-79-4
FormulaC20H28O2
Solubilityinsoluble in H2O; ≥11.9 mg/mL in DMSO; ≥5.77 mg/mL in EtOH with ultrasonic
Chemical Name(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
SDFDownload SDF
Canonical SMILESCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Protocol

Cell experiment [1]:

Cell lines

Mesangial cells

Preparation method

The solubility of this compound in DMSO is > 11.9 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.

Reacting condition

0 ~ 25 μM; 0 ~ 24 hrs

Applications

Tretinoin prevented H2O2-induced cell damage by increasing both the catalase activity and the reduced glutathione level in dose- and time-dependent manners. In mesangial cells, Tretinoin increased the levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being involved in the rate-limiting step for the de novo synthesis of reduced glutathione.

Animal experiment [1]:

Animal models

Male Fischer 344 rats

Dosage form

1 mg/kg/day; p.o.

Applications

In male Fischer 344 rats, Tretinoin at the dose of 1 mg/kg/day did not caused any toxic effect. Compared with age-matched control animals, rats treated with Tretinoin showed lower protein content in the renal cortex. But there was no difference in the DNA content of the renal cortex between the control group and the Tretinoin treatment group.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Manzano VM, Puyol MR, Puyol DR, et al. Tretinoin prevents age-related renal changes and stimulates antioxidant defenses in cultured renal mesangial cells. J Pharmacol Exp Ther, 1999, 289(1): 123-132.

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