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Timolol Maleate

Catalog No.
B1350
Non-selective, beta-adrenergic receptor antagonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
100mg
$50.00
In stock
250mg
$105.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt432.49
Cas No.26921-17-5
FormulaC17H28N4O7S
Solubility≥21.62 mg/mL in DMSO; ≥10.53 mg/mL in EtOH; ≥11.83 mg/mL in H2O
Chemical Name(Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
SDFDownload SDF
Canonical SMILESCC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Protocol

Animal experiment:[1]

Animal models

Adult male Wistar rats, 9 weeks of age, 250 ~ 300 g

Dosage form

0.5% timolol maleate

Topically applied daily, started 1 week after the laser photocoagulation and lasted for 3 weeks

Applications

In rats subjected to intracameral injection of India ink and subsequent laser trabecular photocoagulation, timolol maleate induced a significant reduction in intraocular pressure (IOP) and counteracted the reduction in retinal ganglion cell (RGC) number that occurred in vehicle treated glaucomatous eyes. Thus, timolol maleate was able to reduce IOP and protected RGCs in a rat model of experimental glaucoma.

Note

The technical data provided above is for reference only.

References:

1. Seki M, Tanaka T, Matsuda H, et al. Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. British Journal of Ophthalmology, 2005, 89(4): 504-507.

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