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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
Plasmodium falciparum
Preparation method
The solubility of this compound in DMSO is ≥7.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
380 uM
Applications
Sulfanilamide moderately inhibits the Plasmodium falciparum growth.
Animal models
Male, immunosuppressed Sprague-Dawley rats
Dosage form
100, 10, and 1.0 mg/kg/day
Application
Sulfanilamide effectively inhibited P.carinii infection in immunosuppressed rat model with a concentration of 100.0 mg/kg /day. When the dose of Sulfanilamide was reduced to 10.0 mg/kg/day, P. carinii infection occurred.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Kasekarn W, Sirawaraporn R, Chahomchuen T, Cowman AF, Sirawaraporn W. Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum. Mol Biochem Parasitol. 2004 Sep;137(1):43-53. PubMed PMID: 15279950.
[2]. Hughes WT, Killmar J. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. PubMed PMID: 8849260; PubMed Central PMCID: PMC163239.