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SJB3-019A

In stock
Catalog No.
B1307
Usp1 inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$210.00
In stock
5mg
$220.00
In stock
10mg
$350.00
In stock
50mg
$820.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].

Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].

SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].

Reference:
[1].  Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt276.25
FormulaC16H8N2O3
Solubility≥10.85mg/mL in DMSO with gentle warming
Chemical Name2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
SDFDownload SDF
Canonical SMILESO=C(C1=C2OC(C3=CN=CC=C3)=N1)C4=CC=CC=C4C2=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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