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Search results for: 'research-area tyrosine-kinase'

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  1. Pazopanib (GW-786034)
    A3022 Pazopanib (GW-786034)
    Target: CSF-1R|VEGFR|PDGFR|c-Kit|FGFR
    Summary: VEGFR/PDGFR/FGFR inhibitor
      ≥10.95 mg/mL
      <2.52 mg/mL
      <2.76 mg/mL
  2. Imatinib Mesylate (STI571)
    A1805 Imatinib Mesylate (STI571)
    Target: PDGFR|c-Kit|Bcr-Abl
    Summary: Abl/c-kit/PDGFR inhibitor
      ≥29.5 mg/mL
  3. Masitinib (AB1010)
    A2942 Masitinib (AB1010)
    Target: PDGFR|c-Kit|Lyn
    Summary: Tyrosine kinase inhibitor, potent and selective
      ≥24.95 mg/mL
  4. Regorafenib
    A8236 Regorafenib
     4 Citation
    Target: Raf|VEGFR|PDGFR|c-Kit|RET
    Summary: Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1
      ≥25.0415 mg/mL
      ≥6.25 mg/mL
      <2.12 mg/mL
  5. Regorafenib hydrochloride
    A3750 Regorafenib hydrochloride
    Target: Raf|VEGFR|PDGFR|c-Kit|c-RET
    Summary: Tyrosine kinase inhibitor
      ≥25.95 mg/mL
      ≥8.75 mg/mL
      <2.91 mg/mL
  6. Dasatinib Monohydrate
    B5954 Dasatinib Monohydrate
    Target: PDGFR|c-Kit|Bcr-Abl|Src
    Summary: Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases.
      ≥25.3 mg/mL
  7. Dovitinib (TKI258) Lactate
    B5953 Dovitinib (TKI258) Lactate
    Target: CSF-1R|FLT3|VEGFR|PDGFR|c-Kit|FGFR
    Summary: Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR).
      ≥168.2 mg/mL
  8. AZD2932
    B5835 AZD2932
    Target: FLT3|VEGFR|PDGFR|c-Kit
    Summary: inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit
      soluble in dmso
  9. Imatinib (STI571)
    B2171 Imatinib (STI571)
    Target: PDGFR|c-Kit|Bcr-Abl
    Summary: Protein-tyrosine kinase inhibitor
      ≥24.68 mg/mL
  10. Telatinib (BAY 57-9352)
    A8550 Telatinib (BAY 57-9352)
    Target: VEGFR|PDGFR|c-Kit
    Summary: VEGFR-2/-3,PDGFR-β and c-Kit inhibitor
      ≥20.5 mg/mL

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Category
Specificity
  1. Selective 6 items
Target
  1. Cyclin-Dependent Kinases 27 items
  2. Histone Deacetylases (HDACs) 1 item
  3. Akt 4 items
  4. PI3K 16 items
  5. Raf 10 items
  6. Aurora Kinases 22 items
  7. CSF-1R 4 items
  8. mTOR 8 items
  9. FLT3 13 items
  10. GSK-3 9 items
  11. PLK 6 items
  12. Chk 5 items
  13. Eph Receptors 3 items
  14. VEGFR 30 items
  15. PDGFR 22 items
  16. c-Kit 12 items
  17. RET 4 items
  18. IRAK 3 items
  19. Bromodomain-containing proteins(BRDs) 1 item
  20. p38 6 items
  21. PKB 1 item
  22. JNK 2 items
  23. SGK 2 items
  24. Bcr-Abl 13 items
  25. MEK 5 items
  26. FGFR 12 items
  27. Pim 4 items
  28. Voltage-gated Sodium (NaV) Channels 1 item
  29. Ribosomal s6 kinases (RSK) 1 item
  30. MET 5 items
  31. Src 17 items
  32. Trk Receptors 3 items
  33. STAT 3 items
  34. EGFR 19 items
  35. ROCK 7 items
  36. BTK 1 item
  37. PAK 3 items
  38. FAK 5 items
  39. BMP and Other Activin Receptors 2 items
  40. JAK 16 items
  41. Syk 5 items
  42. DNA-PK 5 items
  43. AMPK 2 items
  44. PDHK 1 item
  45. Cytochrome P450 (CYP450) 1 item
  46. ErbB 4 items
  47. S6 kinases 1 item
  48. Adenosine Kinases 2 items
  49. ERK 4 items
  50. Kinases 1 item
  51. c-MET 5 items
  52. PKC 12 items
  53. Ubiquitin-specific proteases 1 item
  54. Ca2 /calmodulin-dependent protein kinases (CaMKs) 6 items
  55. Lyn 2 items
  56. HER2 2 items
  57. Pyk2 3 items
  58. LRRK2 6 items
  59. Insulin and Insulin-like Receptors 4 items
  60. ALK 6 items
  61. ROS1 1 item
  62. Sphingosine kinases (SphKs) 2 items
  63. PKG 2 items
  64. PKA 5 items
  65. Myosin light chain kinases (MLCKs) 2 items
  66. CaM-KK 1 item
  67. MELK 1 item
  68. Insulin-like growth factors (IGFs) 1 item
  69. Clk 1 item
  70. NUAK1 1 item
  71. NUAK2 1 item
  72. MK2 2 items
  73. Fatty-acid-binding proteins (FABPs) 1 item
  74. Angiotensin-Converting Enzymes (ACEs) 1 item
  75. Tie-2 2 items
  76. RSK 2 items
  77. phosphatases 1 item
  78. ATM/ATR 4 items
  79. CK1 1 item
  80. Farnesyl Diphosphate Synthases 1 item
  81. CK2 3 items
  82. HIPK2 1 item
  83. HIPK3 1 item
  84. P2X Receptors 1 item
  85. c-Fyn 1 item
  86. TAK1 1 item
  87. P110 1 item
  88. Hck 2 items
  89. MNK 1 item
  90. 5-Lipoxygenases 1 item
  91. Insulin Receptors 1 item
  92. IRG-1R 1 item
  93. Cdc2-like kinase (Clk) 1 item
  94. eEF-2 1 item
  95. Cdc7 2 items
  96. ZAP-70 1 item
  97. c-RET 3 items
  98. p70 rsk 2 items
  99. VEGFR3/FLT4 1 item
  100. NTRK1/TRKA 1 item
  101. CSF-1R/c-Fms 1 item
  102. TAM kinase 1 item
  103. KDR 1 item
  104. Fyn kinase 1 item
  105. Abl kinases 1 item
  106. AXL 1 item
  107. c-Fms tyrosine kinase 1 item
  108. insulin 1 item
  109. haspin kinase 1 item
  110. STK 1 item
  111. MSK 1 item
  112. Lyn kinase 1 item
  113. Mer tyrosine kinase 1 item
  114. ErbB-2 1 item
  115. PDK-1 1 item
  116. Histone Acetyltransferases (HATs) 1 item
  117. Prk 1 item
  118. ITK 1 item
  119. NUAK 1 item
  120. DCLK2 1 item
  121. PTK 1 item
  122. phosphatidylinositol kinase 1 item
  123. Lck 2 items
  124. Flk1 2 items
  125. Protein Tyrosine Phosphatases 1 item
  126. alkaline phosphatases 1 item
  127. ATPases 1 item
  128. glutamate release 1 item
  129. FGR 1 item
  130. YES 2 items
  131. Fyn 2 items
  132. ARG 1 item
  133. PKD 1 item
  134. Pyruvate kinases 1 item
  135. enoyl-acyl-carrier protein reductase 1 item
  136. Rho-kinase 1 item
  137. tropomyosin receptor kinase 1 item
  138. SK 1 item
  139. PPK 1 item
  140. c-Syk 1 item
  141. CDK1/CyclinB 1 item
  142. PIM1 kinase 1 item
  143. phospholipase A2 1 item
  144. ATM 1 item
  145. PIKfyve 1 item
  146. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 12 items
  2. Cell Experiments 9 items
Related Disease
  1. Adrenocortical Carcinoma 1 item
  2. Bladder Cancer 1 item
  3. Breast Cancer 2 items
  4. Cancer 9 items
  5. Clear Cell Renal Cell Carcinoma 1 item
  6. Colorectal Cancer 4 items
  7. Glioblastoma 1 item
  8. Leukemia 1 item
  9. Melanoma 1 item
  10. Multiple Myeloma 1 item
  11. Pancreatic Cancer 1 item
  12. Renal Cell Carcinoma 1 item