Search results for: 'research-area stem-cell hippo-signaling'
- BMS 309403Catalog No. :B7794FABP4 inhibitor,potent and selective
Potent and selective adipocyte fatty acid binding protein 4 (aFABP4) inhibitor (Ki values are <2, 250 and 350 nM for aFABP4, mFABP4 and eFABP4 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.
- CilomilastCatalog No. :A4329Potent PDE4 inhibitorCilomilast, also known as SB-207499 or Ariflo, is a potent second generation inhibitor of type 4 phosphodiesterase (PDE4), an enzyme metabolizing cellular cyclic adenosine monophosphate (cAMP) which acts as a second messenger to disrupt the function of inflammatory cell and induce airway smooth muscle relaxation.
- Apremilast (CC-10004)Catalog No. :A4317PDE4 inhibitorApremilast, also known as CC-10004, is a novel and potent small-molecule inhibitor of phosphodiesterase 4 (PDE4), a key enzyme involved in cyclic adenosine monophosphate (cAMP) degradation and cytokine production of inflammatory cells.