Search results for: 'research-area stem-cell hippo-signaling'
- AT13387Catalog No. :A4056Hsp90 inhibitor
AT13387, discovered by a high-throughput x-ray craystallography fragment-based platform, is a non-geldanamycin heat shock proterin 90 (HPS90), a molecule chaperone regulating signal transduction pathways for cell growth and survival, inhibitor reportedly resulting in client protein degradation, suppression of signaling, and inducing cell cycle arrest and apoptosis.
- STF-62247Catalog No. :B2151Autophagy inducer in renal cellSTF-62247 shows selectivtoxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).
- Chloroquine diphosphateCatalog No. :A8628Antimalarial drug,TLR7 TLR9 inhibitor
Chloroquine diphosphate is used as an antimalarial drug and also functions to increase sensitivity of tumor cells to radiation and chemotherapy via inducing autophagy .