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  • Search results for: 'research-area stem-cell hippo-signaling'

Search results for: 'research-area stem-cell hippo-signaling'

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Items 1-10 of 24

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  1. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.1 mg/mL
      ≥4.96 mg/mL
      <2.2 mg/mL
  2. CAL-101 (Idelalisib, GS-1101)
    A3005 CAL-101 (Idelalisib, GS-1101)
     2 Citation
    Target: PI3K
    Summary: PI3K inhibitor
      ≥80.2 mg/mL
      ≥2.1 mg/mL
      <2.09 mg/mL
  3. BYL-719
    A8346 BYL-719
     1 Citation
    Target: PI3K
    Summary: Selective PI3Kα inhibitor
      ≥22.1 mg/mL
  4. AZD6482
    A5478 AZD6482
    Target: PI3K
    Summary: PI3Kβ inhibitor,potent and selective
      ≥20.4 mg/mL
      ≥6.36 mg/mL
      <2.35 mg/mL
  5. AS-605240
    A5176 AS-605240
    Target: PI3K
    Summary: Potent and selective PI 3-Kγ inhibitor
      ≥4.28 mg/mL
      <2.45 mg/mL
      <2.43 mg/mL
  6. TG100-115
    A2754 TG100-115
    Target: PI3K
    Summary: PI3Kγ/PI3Kδ inhibitor
      ≥3.46 mg/mL
  7. TGX-221
    A2681 TGX-221
    Target: PI3K
    Summary: PI3Kβ inhibitor,potent,selective and ATP competitive
      ≥68.7 mg/mL
  8. XL147
    A5112 XL147
    Target: PI3K
    Summary: PI3K inhibitor,selective and reversible
      ≥22.45 mg/mL
      <2.53 mg/mL
      <2.43 mg/mL
  9. LY 294002
    A8250 LY 294002
     16 Citation
    Target: PI3K
    Summary: Potent PI3K inhibitor
      ≥15.37 mg/mL
      ≥13.55 mg/mL
      <2.22 mg/mL
  10. VS-5584 (SB2343)
    A3927 VS-5584 (SB2343)
    Target: PI3K|mTOR
    Summary: MTOR/P13K inhibitor,potent and selective
      ≥17.7 mg/mL
      ≥4.71 mg/mL
      <2.23 mg/mL

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  1. Target Toll-like receptors (TLRs) Remove This Item
  2. Target DCLK2 Remove This Item
  3. Target c-Fms tyrosine kinase Remove This Item
  4. Target P-glycoprotein (P-gp) Remove This Item
  5. Target PI3K Remove This Item
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Category
Specificity
  1. Selective 19 items
Reversibility
  1. Reversible 1 item
Target
  1. Caspases 8 items
  2. Cyclin-Dependent Kinases 18 items
  3. Proteasome 7 items
  4. Cathepsins 1 item
  5. Histone Deacetylases (HDACs) 16 items
  6. Inhibitor of apoptosis proteins (IAP) 1 item
  7. Akt 9 items
  8. Bcl-2 2 items
  9. PI3K 17 items
  10. Raf 9 items
  11. Aurora Kinases 6 items
  12. Bcl-xl 1 item
  13. Glycoproteins 1 item
  14. MDM2 1 item
  15. EZH2 3 items
  16. mTOR 9 items
  17. Bromodomains 1 item
  18. AP-1 2 items
  19. MMP 2 items
  20. Androgen Receptors 1 item
  21. Myosin II ATPases 1 item
  22. FLT3 2 items
  23. GSK-3 8 items
  24. LPA Receptors 1 item
  25. P-glycoprotein (P-gp) 3 items
  26. PLK 7 items
  27. Chk 4 items
  28. VEGFR 7 items
  29. PDGFR 4 items
  30. c-Kit 1 item
  31. Bromodomain-containing proteins(BRDs) 1 item
  32. Phosphodiesterases (PDEs) 2 items
  33. Hydrolase 1 item
  34. p38 4 items
  35. PKB 1 item
  36. JNK 4 items
  37. Bcr-Abl 1 item
  38. MEK 7 items
  39. PORCN 1 item
  40. DOT1L 1 item
  41. FGFR 3 items
  42. Glucagon-like peptide 1 (GLP-1) receptors 1 item
  43. Sir2-like Family Deacetylases (Sirtuins) 1 item
  44. Deubiquitinating enzymes (DUBs) 1 item
  45. Smoothened 2 items
  46. Ras 1 item
  47. Src 2 items
  48. Trk Receptors 2 items
  49. STAT 8 items
  50. Microtubules/Tubulins 4 items
  51. Estrogen and Related Receptors 1 item
  52. EGFR 8 items
  53. Hedgehog 1 item
  54. Reverse Transcriptases 1 item
  55. ROCK 7 items
  56. FAK 4 items
  57. BMP and Other Activin Receptors 2 items
  58. JAK 5 items
  59. p300 1 item
  60. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  61. Syk 1 item
  62. DNA-PK 3 items
  63. HSP90 1 item
  64. AMPK 2 items
  65. CCR 1 item
  66. CFTR 3 items
  67. TNKS 1 item
  68. Cytochrome P450 (CYP450) 1 item
  69. ErbB 2 items
  70. Toll-like receptors (TLRs) 2 items
  71. DNA Methyltransferases 1 item
  72. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  73. ERK 3 items
  74. BMI-1 1 item
  75. PKC 10 items
  76. Calpains 1 item
  77. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2 items
  78. Lyn 1 item
  79. SGLT 1 item
  80. RAD51 1 item
  81. Pyk2 3 items
  82. USP 1 item
  83. LRRK2 2 items
  84. Voltage-gated Calcium Channels (CaV) 1 item
  85. Insulin and Insulin-like Receptors 1 item
  86. Mitochondrial apoptosis-induced channel (MAC) 1 item
  87. ALK 4 items
  88. Sphingosine kinases (SphKs) 1 item
  89. GTPases 1 item
  90. PKG 1 item
  91. PKA 6 items
  92. Fatty-acid-binding proteins (FABPs) 1 item
  93. Tie-2 1 item
  94. RSK 1 item
  95. Granzyme B 1 item
  96. Free Fatty Acid Receptors 1 item
  97. phosphatases 1 item
  98. Autophagy 2 items
  99. ATM/ATR 5 items
  100. CK1 1 item
  101. Farnesyl Diphosphate Synthases 1 item
  102. HIV Integrases 1 item
  103. Melatonin Receptors 1 item
  104. Peroxynitrite 1 item
  105. MAGL 1 item
  106. NPY Receptors 1 item
  107. c-Fyn 1 item
  108. Histamine H1 Receptors 2 items
  109. RAR/RXR 1 item
  110. TRP Channel 1 item
  111. DYRK 1 item
  112. Apoptosis Inducers 1 item
  113. MNK 1 item
  114. NO Donors / Precursors 1 item
  115. Glucocorticoid Receptors 1 item
  116. IL Receptors 1 item
  117. 15-lipoxygenases 1 item
  118. Inward Rectifier Potassium (Kir) Channels 2 items
  119. Peptidoglycan synthesis 1 item
  120. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  121. NMDA receptor 1 item
  122. Aldosterone receptor 1 item
  123. RNA synthesis 1 item
  124. BACE 1 item
  125. DPP-4 1 item
  126. DREADD Ligands 1 item
  127. p70 rsk 2 items
  128. Microtubule/Tubulin 2 items
  129. p53-MDM2 interaction 1 item
  130. KDR 1 item
  131. p53 3 items
  132. c-Fms tyrosine kinase 1 item
  133. insulin 1 item
  134. Ub-conjugating enzyme (E2) complex 1 item
  135. Smoothened receptor 1 item
  136. PPAR 1 item
  137. HDM2 ubiquitin ligase 1 item
  138. Glucosidases 1 item
  139. Vitamin D receptors (VDRs) 1 item
  140. Antibiotic 1 item
  141. DNA Alkylating 1 item
  142. GLI 1 item
  143. Stem Cell Differentiation 1 item
  144. PP2A/Nkd interaction 1 item
  145. adrenergic receptor 1 item
  146. Prk 1 item
  147. Ribonucleotide Reductases 1 item
  148. Rho 1 item
  149. Aryl hydrocarbon receptors (AHRs) 1 item
  150. DCLK2 1 item
  151. phosphatidylinositol kinase 1 item
  152. Lck 1 item
  153. Adenosine Deaminases 1 item
  154. Histamine receptors 1 item
  155. GluR 1 item
  156. 5-HT receptor 1 item
  157. dopamine receptors 1 item
  158. AMPA receptor 1 item
  159. Flk1 1 item
  160. p21 1 item
  161. RHA 1 item
  162. FKBP 1 item
  163. Bcl-w 1 item
  164. PPK 1 item
  165. c-Syk 1 item
  166. CDK1/CyclinB 1 item
  167. glucose uptake 1 item
  168. FXR 1 item
  169. Vascular Disrupting Agents (VDA) 1 item
  170. ATM 1 item
  171. Sirtuin 1 item
  172. PIKfyve 1 item
  173. Bax 1 item
  174. NS3/4a Proteases 1 item
  175. p90 S6K 1 item
Reported Experiments
  1. Animal Experiments 22 items
  2. Cell Experiments 18 items
Related Disease
  1. Breast Cancer 4 items
  2. Cancer 13 items
  3. Cholangiocarcinoma 1 item
  4. Chronic Lymphocytic Leukemia 1 item
  5. Colon Cancer 1 item
  6. Colorectal Cancer 2 items
  7. Glioblastoma 1 item
  8. Glioma 2 items
  9. Hepatocellular Carcinoma 1 item
  10. Lung Cancer 1 item
  11. Neuroblastoma 1 item
  12. Non-small Cell Lung Cancer 2 items
  13. Ovarian Cancer 2 items
  14. Pancreatic Cancer 1 item
  15. Pancreatic Carcinoma 1 item
  16. Prostate Cancer 1 item
  17. Rheumatoid Arthritis 1 item