Search results for: 'research-area stem-cell hippo-signaling'
- TAK-242Catalog No. :A3850TLR 4 signaling inhibitor
IC50: With IC50 of 1.1 to 11 nM, TAK-242 inhibited LPS-induced NO production, tumor necrosis factor-alpha and interleukin (IL)-6 in RAW264.7 cells and mouse peritoneal macrophages .
- ImiquimodCatalog No. :A5161TLR-7 agonist,immunomodulator with antiviral and antitumor activityIC50: Imiquimod activates toll-like receptor 7 (EC50 2.1 μM) on immune cells and also enables an OGF-mediated block of cell proliferation (IC50 2 μM) .
- 2,3-DCPE hydrochlorideCatalog No. :A4447Bcl-XL protein expression downregulatorSelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.