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 Paper Citing APExBIO Products  Ongoing Clinical Trials  Solubility in DMSO  Solubility in Water  Solubility in Ethanol  Solubility in Dimethyl Formamide
  1. SB 203580
    A8254 SB 203580
     9 Citation
    Target: p38|PKB
    Summary: P38 MAP kinase inhibitor
      ≥18.872 mg/mL
      ≥3.28 mg/mL
      <2.68 mg/mL
  2. Gefitinib (ZD1839)
    A8219 Gefitinib (ZD1839)
     3 Citation
    Target: EGFR
    Summary: Selective EGFR inhibitor
      ≥22.3 mg/mL
      ≥2.48 mg/mL
      <2.76 mg/mL
  3. Epidermal Growth Factor (EGF), human recombinant
    P1008 Epidermal Growth Factor (EGF), human recombinant
    Target: EGFR
    Summary: EGF, expressed in E.Coli, His-tag, suitable for cell culture.
  4. Gefitinib hydrochloride
    A3433 Gefitinib hydrochloride
    Target: EGFR
    Summary: Potent EGFR inhibitor
      ≥6.9 mg/mL
      <2.16 mg/mL
      ≥4.28 mg/mL
  5. Latrepirdine
    B1572 Latrepirdine
    Target: Voltage-gated Calcium Channels (CaV)|NMDA receptor|adrenergic receptor|Histamine receptors|GluR|5-HT receptor|dopamine receptors|AMPA receptor
    Summary: Brain cell death inhibitor
      ≥19.6185 mg/mL
  6. AZD8931 (Sapitinib)
    A8375 AZD8931 (Sapitinib)
    Target: EGFR|ErbB
    Summary: ErbB inhibitor
      ≥23.7 mg/mL
      ≥57.8 mg/mL
      <2.49 mg/mL
  7. AG-1478
    A8357 AG-1478
    Target: EGFR
    Summary: EGFR inhibitor,potent and selective
      ≥15.8 mg/mL
  8. Neratinib (HKI-272)
    A8322 Neratinib (HKI-272)
     1 Citation
    Target: EGFR
    Summary: HER2/EGFR inhibitor,potent and irreversible
      ≥13.9 mg/mL
  9. PD168393
    A2024 PD168393
    Target: PDGFR|FGFR|EGFR|PKC|insulin
    Summary: EGFR inhibitor
      ≥18.45 mg/mL
  10. PR-619
    A8212 PR-619
    Target: Deubiquitinating enzymes (DUBs)
    Summary: Deubiquitylating enzymes (DBUs) inhibitor
      ≥11.15 mg/mL
      <2.65 mg/mL
      <2.5 mg/mL

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Category
  • Protein 1item
  • Signaling Pathways 10items
Specificity
  1. Selective 5 items
Reversibility
  1. Reversible 2 items
  2. Irreversible 2 items
Target
  1. Caspases 8 items
  2. Cyclin-Dependent Kinases 18 items
  3. Proteasome 7 items
  4. Cathepsins 1 item
  5. Histone Deacetylases (HDACs) 16 items
  6. Inhibitor of apoptosis proteins (IAP) 1 item
  7. Akt 9 items
  8. Bcl-2 2 items
  9. PI3K 17 items
  10. Raf 9 items
  11. Aurora Kinases 6 items
  12. Bcl-xl 1 item
  13. Glycoproteins 1 item
  14. MDM2 1 item
  15. EZH2 3 items
  16. mTOR 9 items
  17. Bromodomains 1 item
  18. AP-1 2 items
  19. MMP 2 items
  20. Androgen Receptors 1 item
  21. Myosin II ATPases 1 item
  22. FLT3 2 items
  23. GSK-3 8 items
  24. LPA Receptors 1 item
  25. P-glycoprotein (P-gp) 3 items
  26. PLK 7 items
  27. Chk 4 items
  28. VEGFR 7 items
  29. PDGFR 4 items
  30. c-Kit 1 item
  31. Bromodomain-containing proteins(BRDs) 1 item
  32. Phosphodiesterases (PDEs) 2 items
  33. Hydrolase 1 item
  34. p38 4 items
  35. PKB 1 item
  36. JNK 4 items
  37. Bcr-Abl 1 item
  38. MEK 7 items
  39. PORCN 1 item
  40. DOT1L 1 item
  41. FGFR 3 items
  42. Glucagon-like peptide 1 (GLP-1) receptors 1 item
  43. Sir2-like Family Deacetylases (Sirtuins) 1 item
  44. Deubiquitinating enzymes (DUBs) 1 item
  45. Smoothened 2 items
  46. Ras 1 item
  47. Src 2 items
  48. Trk Receptors 2 items
  49. STAT 8 items
  50. Microtubules/Tubulins 4 items
  51. Estrogen and Related Receptors 1 item
  52. EGFR 8 items
  53. Hedgehog 1 item
  54. Reverse Transcriptases 1 item
  55. ROCK 7 items
  56. FAK 4 items
  57. BMP and Other Activin Receptors 2 items
  58. JAK 5 items
  59. p300 1 item
  60. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  61. Syk 1 item
  62. DNA-PK 3 items
  63. HSP90 1 item
  64. AMPK 2 items
  65. CCR 1 item
  66. CFTR 3 items
  67. TNKS 1 item
  68. Cytochrome P450 (CYP450) 1 item
  69. ErbB 2 items
  70. Toll-like receptors (TLRs) 2 items
  71. Actin 1 item
  72. DNA Methyltransferases 1 item
  73. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  74. ERK 3 items
  75. BMI-1 1 item
  76. PKC 10 items
  77. Calpains 1 item
  78. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2 items
  79. Lyn 1 item
  80. SGLT 1 item
  81. RAD51 1 item
  82. Pyk2 3 items
  83. USP 1 item
  84. LRRK2 2 items
  85. Voltage-gated Calcium Channels (CaV) 1 item
  86. Insulin and Insulin-like Receptors 1 item
  87. Mitochondrial apoptosis-induced channel (MAC) 1 item
  88. ALK 4 items
  89. Sphingosine kinases (SphKs) 1 item
  90. GTPases 1 item
  91. PKG 1 item
  92. PKA 6 items
  93. D2 Receptors 1 item
  94. Fatty-acid-binding proteins (FABPs) 1 item
  95. Tie-2 1 item
  96. RSK 1 item
  97. Granzyme B 1 item
  98. Free Fatty Acid Receptors 1 item
  99. phosphatases 1 item
  100. Autophagy 2 items
  101. ATM/ATR 5 items
  102. CK1 1 item
  103. Farnesyl Diphosphate Synthases 1 item
  104. HIV Integrases 1 item
  105. Melatonin Receptors 1 item
  106. Peroxynitrite 1 item
  107. MAGL 1 item
  108. NPY Receptors 1 item
  109. c-Fyn 1 item
  110. Histamine H1 Receptors 3 items
  111. RAR/RXR 1 item
  112. TRP Channel 1 item
  113. DYRK 1 item
  114. Apoptosis Inducers 1 item
  115. MNK 1 item
  116. NO Donors / Precursors 1 item
  117. Glucocorticoid Receptors 1 item
  118. IL Receptors 1 item
  119. 15-lipoxygenases 1 item
  120. Inward Rectifier Potassium (Kir) Channels 2 items
  121. Peptidoglycan synthesis 1 item
  122. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  123. NMDA receptor 1 item
  124. Aldosterone receptor 1 item
  125. RNA synthesis 1 item
  126. BACE 1 item
  127. DPP-4 1 item
  128. DREADD Ligands 1 item
  129. p70 rsk 2 items
  130. Microtubule/Tubulin 2 items
  131. p53-MDM2 interaction 1 item
  132. KDR 1 item
  133. p53 3 items
  134. c-Fms tyrosine kinase 1 item
  135. insulin 1 item
  136. Ub-conjugating enzyme (E2) complex 1 item
  137. Smoothened receptor 1 item
  138. PPAR 1 item
  139. HDM2 ubiquitin ligase 1 item
  140. Glucosidases 1 item
  141. Vitamin D receptors (VDRs) 1 item
  142. Antibiotic 1 item
  143. DNA Alkylating 1 item
  144. GLI 1 item
  145. Stem Cell Differentiation 1 item
  146. PP2A/Nkd interaction 1 item
  147. adrenergic receptor 1 item
  148. Prk 1 item
  149. Ribonucleotide Reductases 1 item
  150. Rho 1 item
  151. Aryl hydrocarbon receptors (AHRs) 1 item
  152. DCLK2 1 item
  153. phosphatidylinositol kinase 1 item
  154. Lck 1 item
  155. Adenosine Deaminases 1 item
  156. Histamine receptors 1 item
  157. GluR 1 item
  158. 5-HT receptor 1 item
  159. dopamine receptors 1 item
  160. AMPA receptor 1 item
  161. Flk1 1 item
  162. p21 1 item
  163. RHA 1 item
  164. TRPC channel 1 item
  165. FKBP 1 item
  166. Bcl-w 1 item
  167. PPK 1 item
  168. c-Syk 1 item
  169. CDK1/CyclinB 1 item
  170. glucose uptake 1 item
  171. FXR 1 item
  172. Vascular Disrupting Agents (VDA) 1 item
  173. ATM 1 item
  174. Sirtuin 1 item
  175. PIKfyve 1 item
  176. Bax 1 item
  177. NS3/4a Proteases 1 item
  178. p90 S6K 1 item
Reported Experiments
  1. Animal Experiments 8 items
  2. Cell Experiments 9 items
Related Disease
  1. Bladder Cancer 2 items
  2. Breast Cancer 4 items
  3. Cancer 6 items
  4. Colorectal Cancer 3 items
  5. Glioblastoma 2 items
  6. Liver Cancer 1 item
  7. Non-small Cell Lung Cancer 1 item
  8. Ovarian Cancer 1 item
  9. Pancreatic Cancer 2 items
  10. Prostate Cancer 2 items