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 Paper Citing APExBIO Products  Ongoing Clinical Trials  Solubility in DMSO  Solubility in Water  Solubility in Ethanol  Solubility in Dimethyl Formamide
  1. LY2090314
    A3570 LY2090314
    Target: GSK-3
    Summary: Potent GSK-3 inhibitor
      ≥91 mg/mL
      ≥4.27 mg/mL
      <2.63 mg/mL
  2. Dabrafenib Mesylate (GSK-2118436)
    A3347 Dabrafenib Mesylate (GSK-2118436)
    Target: Raf
    Summary: Inhibitor of BRAF(V600) mutants
      ≥30.75 mg/mL
      ≥2.74 mg/mL
      <2.25 mg/mL
  3. AS-605240
    A5176 AS-605240
    Target: PI3K
    Summary: Potent and selective PI 3-Kγ inhibitor
      ≥4.28 mg/mL
      <2.45 mg/mL
      <2.43 mg/mL
  4. GDC-0879
    A5071 GDC-0879
     1 Citation
    Target: Raf
    Summary: B-Raf inhibitor,potent and selective
      ≥16.7 mg/mL
      <2.3 mg/mL
      <2.62 mg/mL
  5. Sorafenib Tosylate
    A8245 Sorafenib Tosylate
     1 Citation
    Target: Raf|VEGFR
    Summary: Raf kinases and tyrosine kinases inhibitor
      ≥31.85 mg/mL
      ≥4.15 mg/mL
      <2.41 mg/mL
  6. TAK-632
    A8226 TAK-632
    Target: Raf
    Summary: Pan-RAF inhibitor,potent and selective
      ≥27.75 mg/mL
      ≥2.23 mg/mL
      <2.16 mg/mL
  7. Trametinib (GSK1120212)
    A3018 Trametinib (GSK1120212)
     7 Citation
    Target: MEK
    Summary: MEK1 and MEK2 inhibitor, potent and selective
      ≥15.38 mg/mL
  8. Vemurafenib (PLX4032, RG7204)
    A3004 Vemurafenib (PLX4032, RG7204)
     9 Citation
    Target: Raf
    Summary: BRAF kinase inhibitor
      ≥24.5 mg/mL
  9. PD 0332991 (Palbociclib) HCl
    A8316 PD 0332991 (Palbociclib) HCl
     5 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK4/6 inhibitor,highly selective
      ≥2.4 mg/mL
      ≥2.79 mg/mL
      ≥24.2 mg/mL
  10. C646
    B1577 C646
     1 Citation
    Target: p300
    Summary: HAT p300-CBP inhibitor,cell-permeable
      ≥11.1 mg/mL

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