Search results for: 'research-area stem-cell hippo-signaling'
- GDC-0449 (Vismodegib)Catalog No. :A3021Hedgehog antagonist,potent and selective
GDC-0449 (2-chloro-N-[4-chloro-3-pyridin-2-yl-phenyl]-4-methane-sulfonyl benzamide), discovered by high throughput screening of a small molecule compound library followed by subsequent optimization through medical chemistry, is a potent and selective inhibitor of hedgehog (Hh) signaling, a pathway regulating cell growth and differentiation associated in pathogenesis of several cancers.
- BMS-833923Catalog No. :A3258Smoothened inhibitor
BMS-833923 is an orally bioavailable and selective antagonist of smoothened (SMO) with IC0 value of 5.8 nM in NIH3T3 cell line .