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Search results for: 'research-area stem-cell hippo-signaling'

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Items 1-10 of 39

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  1. Cyclopamine
    A8340 Cyclopamine
     1 Citation
    Target: Smoothened
    Summary: Hedgehog (Hh) signaling Inhibitor
      ≥6.9 mg/mL
  2. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.1 mg/mL
      ≥4.96 mg/mL
      <2.2 mg/mL
  3. LY2090314
    A3570 LY2090314
    Target: GSK-3
    Summary: Potent GSK-3 inhibitor
      ≥91 mg/mL
      ≥4.27 mg/mL
      <2.63 mg/mL
  4. Dabrafenib Mesylate (GSK-2118436)
    A3347 Dabrafenib Mesylate (GSK-2118436)
    Target: Raf
    Summary: Inhibitor of BRAF(V600) mutants
      ≥30.75 mg/mL
      ≥2.74 mg/mL
      <2.25 mg/mL
  5. SB202190 (FHPI)
    A1632 SB202190 (FHPI)
     5 Citation
    Target: p38
    Summary: P38 MAPK inhibitor
      ≥57 mg/mL
      ≥22.47 mg/mL
      <1.71 mg/mL
  6. BYL-719
    A8346 BYL-719
     1 Citation
    Target: PI3K
    Summary: Selective PI3Kα inhibitor
      ≥22.1 mg/mL
  7. LY2228820
    A5566 LY2228820
     1 Citation
    Target: p38
    Summary: P38 MAP kinase inhibitor
      ≥30.65 mg/mL
      ≥9.9 mg/mL
      ≥45 mg/mL
  8. GDC-0879
    A5071 GDC-0879
     1 Citation
    Target: Raf
    Summary: B-Raf inhibitor,potent and selective
      ≥16.7 mg/mL
      <2.3 mg/mL
      <2.62 mg/mL
  9. Sorafenib Tosylate
    A8245 Sorafenib Tosylate
     1 Citation
    Target: Raf|VEGFR
    Summary: Raf kinases and tyrosine kinases inhibitor
      ≥31.85 mg/mL
      ≥4.15 mg/mL
      <2.41 mg/mL
  10. TAK-632
    A8226 TAK-632
    Target: Raf
    Summary: Pan-RAF inhibitor,potent and selective
      ≥27.75 mg/mL
      ≥2.23 mg/mL
      <2.16 mg/mL

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Specificity
  1. Selective 36 items
  2. Non-Selective 1 item
Reversibility
  1. Reversible 1 item
Target
  1. Caspases 1 item
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  6. Aurora Kinases 1 item
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  20. p300 1 item
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  24. Sphingosine kinases (SphKs) 1 item
  25. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  26. Vascular Disrupting Agents (VDA) 1 item
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