Search results for: 'research-area stem-cell hippo-signaling'
- PLX-4720Catalog No. :A3016BRAF kinase inhibitor
PLX-4720, a 7-azaindole derivative discovered by a structure-guided discovery approach, is a potent inhibitor of B-RafV600E, the most frequent oncogenic protein kinase mutation, with the value of 50% inhibition concentration IC50 of 13 nM.
- SorafenibCatalog No. :A3009Raf kinases and tyrosine kinases inhibitor
Sorafenib is an oral multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit. sorafenib, inhibits tumor growth and disrupts tumor microvasculature through antiproliferative, antiangiogenic, and/or proapoptotic effects.
- Gefitinib (ZD1839)Catalog No. :A8219Selective EGFR inhibitor
Gefitinib, also known as ZD1839 or Iressa, is a potent and orally-bioavailable small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with 50% inhibition concentration IC50 values of 0.033 μM and 0.027 μM in A431 membrane prep and baculovirus lysate respectively.
- PhloretinCatalog No. :A3723A dihydrochalcone found in apple
Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2. Phloretin can block other glucose transporter including GLUT1.