Search results for: 'research-area stem-cell hippo-signaling'
- SorafenibCatalog No. :A3009Raf kinases and tyrosine kinases inhibitor
Sorafenib is an oral multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit. sorafenib, inhibits tumor growth and disrupts tumor microvasculature through antiproliferative, antiangiogenic, and/or proapoptotic effects.
- SNS-032 (BMS-387032)Catalog No. :A1980CDK inhibitor
Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
- Gefitinib (ZD1839)Catalog No. :A8219Selective EGFR inhibitor
Gefitinib, also known as ZD1839 or Iressa, is a potent and orally-bioavailable small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with 50% inhibition concentration IC50 values of 0.033 μM and 0.027 μM in A431 membrane prep and baculovirus lysate respectively.
- Bortezomib (PS-341)Catalog No. :A2614Proteasome Inhibitor
A potent (Ki = 0.6 nM), specific and reversible proteasome inhibitor. It inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC₅₀ of 0.1 µM.
- PhloretinCatalog No. :A3723A dihydrochalcone found in apple
Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2. Phloretin can block other glucose transporter including GLUT1.