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 Paper Citing APExBIO Products  Ongoing Clinical Trials  Solubility in DMSO  Solubility in Water  Solubility in Ethanol  Solubility in Dimethyl Formamide
  1. Epothilone B (EPO906, Patupilone)
    A1630 Epothilone B (EPO906, Patupilone)
    Target: Microtubules/Tubulins
    Summary: Microtubule stabilizing macrolide
      ≥25.4 mg/mL
  2. Gefitinib (ZD1839)
    A8219 Gefitinib (ZD1839)
     3 Citation
    Target: EGFR
    Summary: Selective EGFR inhibitor
      ≥22.3 mg/mL
      ≥2.48 mg/mL
      <2.76 mg/mL
  3. Nintedanib (BIBF 1120)
    A8252 Nintedanib (BIBF 1120)
     3 Citation
    Target: VEGFR|PDGFR|FGFR
    Summary: VEGFR/PDGFR/FGFR inhibitor
      ≥5.4 mg/mL
      <2.91 mg/mL
      <2.8 mg/mL
  4. SC 144
    A2173 SC 144
     1 Citation
    Target: Glycoproteins
    Summary: Gp130 inhibitor
      ≥16.1 mg/mL
  5. Nu 6027
    A1986 Nu 6027
    Target: Cyclin-Dependent Kinases|ATM/ATR
    Summary: ATR/CDK inhibitor, potent and selective
      ≥12.55 mg/mL
  6. Apremilast (CC-10004)
    A4317 Apremilast (CC-10004)
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4 inhibitor
      ≥23.05 mg/mL
      <2.51 mg/mL
      <2.43 mg/mL
  7. Tariquidar
    A8208 Tariquidar
     2 Citation
    Target: P-glycoprotein (P-gp)
    Summary: P-glycoprotein inhibitor,potent and non-competitive
      ≥16.168 mg/mL
      <2.35 mg/mL
      <2.13 mg/mL
  8. M344
    A4105 M344
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor,potent and cell-permeable
      ≥14.75 mg/mL
      ≥12.88 mg/mL
      <2.5 mg/mL
  9. CI994 (Tacedinaline)
    A4102 CI994 (Tacedinaline)
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      ≥50 mg/mL
      <2.41 mg/mL
      <2.18 mg/mL
  10. Tofacitinib (CP-690550) Citrate
    A4135 Tofacitinib (CP-690550) Citrate
     2 Citation
    Target: JAK
    Summary: Potent JAK inhibitor
      ≥25.22 mg/mL
      <2.53 mg/mL
      ≥3.4 mg/mL

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