Search results for: 'research-area pi3k-akt-signaling'
- A-674563Catalog No. :A8616Akt1/PKA/CDK2 inhibitor,potent and selectiveA-674563 is a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM.
- GSK690693Catalog No. :A5072Pan-AKT inhibitor,ATP-competitive and potentGSK690693 is a pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively [1, 2]. In addition, it also inhibits AMPK (IC50=50 nM), DAPK3 (IC50=81 nM), PAK4, 5, and 6 (IC50=10, 52, 6 nM), as well as the members of AGC kinase family including PKA (IC50=24 nM), PrkX (IC50=5 nM), and PKC isozymes (IC50=2-21 nM) . GSK690693 reversibly occupies the ATP binding pocket of the kinase domain and competes with ATP as shown by crystal structure . It blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner .
- K-252cCatalog No. :A8344Protein kinase inhibitor
Inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM).
- GF 109203XCatalog No. :A8342Protein kinase C,MLCK,PKG and PKA inhibitor
Very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively).
- Go 6976Catalog No. :A8341PKCα/PKCβ1 inhibitorPotent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively).
- Enzastaurin (LY317615)Catalog No. :A1670PKC beta inhibitor,potent and selective
Enzastaurin is an ATP-competitive, selective oral inhibitor of protein kinase Cβ with IC50 value of 6 nM .