Search results for: 'research-area pi3k-akt-signaling'
- CHIR-99021 (CT99021)Catalog No. :A3011GSK-3 inhibitor, Cell-permeable, ATP-competitive
CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor which can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β).
- BMS 309403Catalog No. :B7794FABP4 inhibitor,potent and selective
Potent and selective adipocyte fatty acid binding protein 4 (aFABP4) inhibitor (Ki values are <2, 250 and 350 nM for aFABP4, mFABP4 and eFABP4 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.