Search results for: 'research-area gpcr-g-protein'
- Dabrafenib Mesylate (GSK-2118436)Catalog No. :A3347Inhibitor of BRAF(V600) mutantsGSK2118436 is a selective BRAF V600E inhibitor. BRAF encodes a proto-oncogene B-Raf also known as serine/threonine protein kinase B-Raf. It is critical in regulating the MAPK/ERK signaling pathway. BRAF mutations frequently occur in many human cancers. [1, 2] BRAF V600E mutant is constitutively active, allowing MAPK/ERK activation independent of upstream cues.
- PLX-4720Catalog No. :A3016BRAF kinase inhibitor
PLX-4720, a 7-azaindole derivative discovered by a structure-guided discovery approach, is a potent inhibitor of B-RafV600E, the most frequent oncogenic protein kinase mutation, with the value of 50% inhibition concentration IC50 of 13 nM.