Search results for: 'her2'
- Afatinib (BIBW2992)Catalog No. :A8247Irreversible EGFR/HER2 inhibitorAfatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.
- TAK-285Catalog No. :A8528HER2/EGFR(HER1) inhibitorTAK-285 exhibits potent inhibitory activity against Neu with IC50 of 260 nM.
- Neratinib (HKI-272)Catalog No. :A8322HER2/EGFR inhibitor,potent and irreversible
Neratinib (HKI-272) is a potent inhibitor of HER-2 and is highly active against HER-2-overexpressing human breast cancer cell lines in vitro.
- AC480 (BMS-599626)Catalog No. :A2822HER1/2 inhibitor,selective and efficaciousAC480 (BMS-599626) is a potent, selective inhibitor of human epidermal growth factor receptor (HER) that inhibits HER1 and HER2 with IC values of 20 nM and 30 nM, respectively. AC480 has been proved to inhibit HER1 in an ATP-competitive manner. On the contrary, AC480 has shown to be an ATP noncompetitive inhibitor of HER2
- CP-724714Catalog No. :A2412HER2 inhibitor,potent and selectiveCP-724714 is an inhibitor of erbB2 and EGFR kinases with IC50 values of 10±3 nmol/L and 6,400±2,100 nmol/L, respectively .
- LapatinibCatalog No. :A8218EGFR/HER2 inhibitor,potent,selective and reversible
Lapatinib (also known as GW572016), a member of the 4-anilinoquinazoline class of kinase inhibitors, is a potent, reversible and selective small-molecule inhibitor of both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases that inhibits recombinant EGFR and HER-2 tyrosine kinases in cell-free biochemical kinase assays with values of 50% inhibition concentration IC50 of 10.8 nmol/L and 9.3 nmol/L respectively.
- Lapatinib DitosylateCatalog No. :A3967EGFR/HER2 inhibitor,potent and selective
Lapatinib Ditosylateis a selective dual inhibitor of ErbB-2 and EGFR with IC50 value against ErbB-2 and EGFR of 9.8 and 10.2 nM in vitro, respectively.
- BMS-599626 HydrochlorideCatalog No. :A3252EGFR/HER2 inhibitor,potent and selectiveBMS-599626 is a selective inhibitor of HER1 and HER2 with IC50 value of 22 nM and 32 nM, respectively .
- CUDC-101Catalog No. :A4092Multitargeted HDAC inhibitorCUDC-101 is a multitargeted inhibitor of histone deacetylase. It is designed to directly inhibit epidermal growth factor receptor (EGFR) and HER2 as well as class I and class II HDACs.
- Pelitinib (EKB-569)Catalog No. :A1835EGFR inhibitor,potent and irreversiblePelitinib (also known as EKB-569), a 3-cyanoquinoline, is a potent, and irreversible inhibitor of epidermal growth factor receptor (EGF-R) tyrosine kinase that inhibits the activity of EGF-R with the half maximal inhibition concentration IC50 value of 38.5 nM in vitro .