Search results for: 'TGF β'
Items 1-10 of 41
- DiscoveryProbe™ TGF-beta/Smad Compound LibraryCatalog No. :L1045A unique collection of 60 TGF-beta/Smad inhibitors for TGF-beta/Smad signaling pathway research.
- TGF-beta1, human recombinant protein (CHO cells)Catalog No. :P1039TGF-β1, pleiotropic cytokine, expressed in CHO cells.
Transforming Growth Factor-β1 (TGF-β1) is a pleiotropic cytokine mainly produced by platelets and bone, and regulates cell proliferation, growth, differentiation and motility.
- LY2109761Catalog No. :A8464TβRI/II kinase inhibitorLY2109761 is a small-molecule inhibitor selectively targeting both TGF-β receptor type I and II ((TβRI/II)) with Ki of 38 nM and 300 nM, respectively . It gave IC50 value of 69 nM in TβRI enzymatic assay . Crystal structure showed the binding of LY2109761 to the ATP binding site of the TGF-β R1 kinase domain . Weak inhibitory activities were reported for other kinases, including Lck, Sapk2α, MKK6, Fyn, and JNK3 (18–89% inhibition at 20 µM) .
- SD-208Catalog No. :A3808TGF-βR I kinase inhibitorSD-208 inhibits the growth inhibition of TGF-β–sensitive CCL64 cells at an EC50 of 0.1 μmol/L
- LY2157299Catalog No. :A8348TGF-βR1 inhibitor,potent and selective
LY2157299 is a potent small-molecule antagonist that specifically inhibits Transforming Growth Factor-β receptor I (TβRI).
- GW788388Catalog No. :A8301ALK5 inhibitor,potent and selectiveGW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)].
- SB525334Catalog No. :A5602(TGF-beta1) receptor inhibitorSB525334 is a potent inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, activin receptor-like kinase (ALK5). It specifically inhibits ALK5 with IC50 value of 14.3nM, which shows 4-fold higher potency against ALK4 .
- SB-505124 hydrochlorideCatalog No. :A3799ALK5/ALK4/ALK7 inhibitor in TGF-β/activin signalling,selectiveSB-505124 is the most suitable molecule for use as an inhibitor of ALKs 4, 5 and 7 and the TGF pathway.
- A 83-01Catalog No. :A3133ALK-5 inhibitorA 83-01 is a small-molecule inhibitor of activin receptorlike kinase (ALK)-5 with IC50 value of 12 nM.
- A 77-01Catalog No. :A3132Potent ALK5 inhibitorTransforming growth factor (TGF)-β signaling facilitates tumor growth and metastasis in advanced cancer.