Search results for: 'A823'
- CA-074 MeCatalog No. :A8239Cathepsin B inhibitor
CA-074 Me is a membrane-permeable and selective inhibitor of cathepsin B with IC50 value of 36.3 nM [1, 2].
- VX-765Catalog No. :A8238Caspase-1 inhibitor,potent and selective
VX-765, an orally- absorbed pro-drug of VRT-043198, is a potent and selective inhibitor of caspase-1 which belongs to the ICE/caspase-1 sub-family caspases.
- SKLB610Catalog No. :A8237Potent VEGFR inhibitorSKLB610 is a selective inhibitor of VEGFR with IC50 value of 2.2 μM .
- RegorafenibCatalog No. :A8236Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1
Regorafenib (BAY 73-4506) is a novel and orally active multikinase inhibitor of receptor tyrosine kinases VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET, Raf-1, B-RAF and B-RAFV600E with IC50 values of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM, 2.5 nM, 28 nM and 19 nM .
- EmbelinCatalog No. :A8235XIAP inhibitor,cell-permeableEmbelin, a natural benzoquinone from plants of the genus Embelia, is an inhibitor of X-linked inhibitor of apoptosis protein (XIAP) with IC50 of 4.1 μM.
- DMXAA (Vadimezan)Catalog No. :A8233Tumnor vascular disrupting agent, apoptosis inducerDMXAA is an apoptosis inducer, and an anti-vascular.
- Erlotinib HydrochlorideCatalog No. :A8234Selective EGFR inhibitor
Erlotinib hydrochloride (the trade name Tarceva®) is a directly acting inhibitor of epidermal growth factor receptor (EGFR/HER-1) tyrosine kinase with an IC50 of 2 nM.
- Nilotinib(AMN-107)Catalog No. :A8232Bcr-Abl kinase inhibitor,selective
Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively .