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Se-Aspirin nonsteroidal anti-inflammatory drug

Catalog No.C5667
Size Price Stock Qty
5mg
$124.00
In stock
10mg
$220.00
In stock
50mg
$894.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

Se-Aspirin

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Chemical Properties

Cas No. 1850293-95-6 SDF Download SDF
Synonyms Selenium-acetylsalicylic Acid
Chemical Name selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester
Canonical SMILES O=C(C)OC1=CC=CC=C1C(NCC[Se]C#N)=O
Formula C12H12N2O3Se M.Wt 311.2
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Se-Aspirin is a novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID) [1].

NSAIDs have demonstrated intestinal antineoplastic effects in various animal intestinal cancer models. Selenium (Se) compounds have attracted a vast interest as promising chemo-preventive agents. Several epidemiological studies have reported an inverse association between the nutritional Se status and cancer risk. Se functioned as chemo-preventive agent for cancer therapy in the past few years.

Se-Aspirin was a hybrid of selenium and a nonsteroidal anti-inflammatory drug. t Se-Aspirin reduced the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells with the IC50 value of 3.4 μM. Se-Aspirin inhibited the cell cycle in G1 and G2/M phases and induced apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin has been reported to cause an increase in intracellular reactive oxygen species levels in CRC cells [1].

Reference:
[1] Plano D, Karelia D N, Pandey M K, et al.  Design, synthesis, and biological evaluation of novel selenium (Se-NSAID) molecules as anticancer agents[J]. Journal of medicinal chemistry, 2016, 59(5): 1946-1959.