SD 1008|Inhibitor of JAK2/STAT3 signaling pathway,apoptosis inducer|CAS# 960201-81-4

Size	Price	Stock	Qty
10mg	$171.00	In stock
50mg	$721.00	In stock

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2018 Mar 29;555(7698):673-677.

Nature.
2017 Sep 7;549(7670):96-100.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nat Nanotechnol.
2017 Dec;12(12):1190-1198.

Nature Biotechnology.
2017 Jun;35(6):569-576

Cell.
2018 Feb 22;172(5):1007-1021.e17.

Cell.
2017 Nov 30;171(6):1284-1300.e21.

Cell.
2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.
2017 Jul 13;170(2):312-323

Nat Med.
2018 Jan 29.

Nat Med.
2017 Nov;23(11):1342-1351.

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2018 May 14;33(5):905-921.e5.

Cancer Cell.
2018 Apr 9;33(4):752-769.e8.

Cancer Cell.
2018 Mar 12;33(3):401-416.e8.

Cancer Cell.
2017 Aug 14;32(2):253-267.e5.

Cell Stem Cell.
2018 May 3;22(5):769-778.e4.

Cell Stem Cell.
2017 Nov 20. pii: S1934-5909(17)30375-2.

Cancer Cell.
2017 May 8;31(5):635-652.e6.

Immunity.
2018 Jan 16;48(1):59-74.e5.

Immunity.
2017 Oct 17;47(4):635-647.e6.

Immunity.
2016 Jan 19;44(1):88-102

Nat Cell Biol.
2018 Feb;20(2):186-197.

Nat Cell Biol.
2017 Dec 11.

Nat Cell Biol.
2015 May;17(5):627-38.

Nat Immunol.
2017 Jun;18(6):654-664.

Sci Transl Med.
2017 Dec 13;9(420). pii: eaal3765.

Quality Control

Quality Control & MSDS

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Purity = 98.00%

Chemical structure

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Chemical Properties

Cas No.	960201-81-4	SDF	Download SDF
Chemical Name	(1R,5R,6S,7R)-dimethyl 8-benzyl-2-oxo-8-azabicyclo[3.2.1]oct-3-ene-6,7-dicarboxylate
Canonical SMILES	O=C([[email protected]]1[[email protected]@H]2C(C=C[[email protected]@H](N2CC3=CC=CC=C3)[[email protected]]1C(OC)=O)=O)OC
Formula	C₁₈H₁₉NO₅	M.Wt	329.35
Solubility	Soluble in DMSO > 10 mM	Storage	Store at RT
Physical Appearance	Yellow solid	Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.