Ristocetin A (sulfate)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1].
Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These two assays could be used to diagnosis the von Willebrand disease and other bleeding disorders [2, 3]. The structural features of Ristocetin A are similar to vancomycin.
References:
[1] Pearson A J, Heo J N. Approaches to the fully functionalized DEF ring system of ristocetin A via highly selective ruthenium-promoted SNAr reaction[J]. Organic letters, 2000, 2(19): 2987-2990.
Hawks G H. Antibiotic therapy of staphylococcal infections[J]. Canadian Medical Association journal, 1965, 93(16): 848.
[3] Castaman, G. ,Hillarp, A. and Goodeve, A. Laboratory aspects of von Willebrand disease: Test repertoire and options for activity assays and genetic analysis. Haemophilia 20(suppl 4), 65-70 (2014).
| Physical Appearance | A powder |
| Storage | Store at -20°C |
| M.Wt | 2166.0 |
| Cas No. | 11140-99-1 |
| Formula | C95H112N8O44·SO4 |
| Synonyms | Ristomycin III |
| Solubility | Soluble in DMSO |
| Chemical Name | ristomycin A, monosulfate |
| Canonical SMILES | CC1C(O)C(N)CC(OC2C3C(NC(C(OC)=O)C4=CC(O)=CC(OC5C(O)C(O)C(O)C(CO)O5)=C4C6=C(O)C=CC(C(NC(C7C8=CC(OC9=CC=C(C(O)C%10C(NC(C(N7)=O)C%11=CC(OC%12=C(O)C=CC(C(N)C(N%10)=O)=C%12)=C(C)C(O)=C%11)=O)C=C9)=C(OC%13C(OC%14C(OC%15C(O)C(O)C(O)CO%15)C(O)C(O)C(CO)O%14)C(O)C( |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. |
Quality Control & MSDS
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Chemical structure
