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Ristocetin A (sulfate)

Catalog No.
C4176
antibiotic that was used to treat staphylococcal infections
Grouped product items
SizePriceStock Qty
10mg
$316.00
Ship with 5-10 days
100mg
$1,107.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1].

Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These two assays could be used to diagnosis the von Willebrand disease and other bleeding disorders [2, 3]. The structural features of Ristocetin A are similar to vancomycin.

References:
[1] Pearson A J, Heo J N.  Approaches to the fully functionalized DEF ring system of ristocetin A via highly selective ruthenium-promoted SNAr reaction[J]. Organic letters, 2000, 2(19): 2987-2990.
Hawks G H.  Antibiotic therapy of staphylococcal infections[J]. Canadian Medical Association journal, 1965, 93(16): 848.
[3] Castaman, G. ,Hillarp, A. and Goodeve, A. Laboratory aspects of von Willebrand disease: Test repertoire and options for activity assays and genetic analysis. Haemophilia 20(suppl 4), 65-70 (2014).

Chemical Properties

Physical AppearanceA powder
StorageStore at -20°C
M.Wt2166.0
Cas No.11140-99-1
FormulaC95H112N8O44·SO4
SynonymsRistomycin III
SolubilitySoluble in DMSO
Chemical Nameristomycin A, monosulfate
Canonical SMILESCC1C(O)C(N)CC(OC2C3C(NC(C(OC)=O)C4=CC(O)=CC(OC5C(O)C(O)C(O)C(CO)O5)=C4C6=C(O)C=CC(C(NC(C7C8=CC(OC9=CC=C(C(O)C%10C(NC(C(N7)=O)C%11=CC(OC%12=C(O)C=CC(C(N)C(N%10)=O)=C%12)=C(C)C(O)=C%11)=O)C=C9)=C(OC%13C(OC%14C(OC%15C(O)C(O)C(O)CO%15)C(O)C(O)C(CO)O%14)C(O)C(
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.

Quality Control

Quality Control & MSDS

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Chemical structure

Ristocetin A (sulfate)