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ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

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  1. Cat.No. Product Name Information
  2. B1294 SR-3677 SR-3677 is a novel, potent and highly selective inhibitor of Rho Kinase (ROCK-II) with the IC50 value of ~0.3nM in enzyme and cell based assays .
  3. B1293 Y-27632 Y-27632 is a specific inhibitor of Rho-associated kinases(ROCK) family with Ki values of 0.22μM and 0.30μM for ROCK1 and ROCK2, respectively.
  4. B1176 Y-39983 dihydrochloride Y-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK .
  5. A5734 Fasudil (HA-1077) HCl Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
  6. A5611 GSK429286A Selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively).
  7. A5506 Thiazovivin Greatly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 and PD 0325901.
  8. A3825 SLx-2119

    SLx-2119(KD-025) is a selective inhibitor of ROCK2 with IC50 of 105 nM [1].

  9. A3773 ROCK inhibitor ROCK inhibitor (Rho-kinase inhibitor) is useful for Anti-cancer.
  10. A3771 RKI-1447 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.
  11. A3642 Narciclasine IC50: The mean IC50 of about 50 nmol/L calculated on the 6 human glioblastoma multiforme was similar to the value previously reported for 6 carcinoma cell lines and consistent with National Cancer Institute data, which also reveal a mean IC50 value of 47 nmol/L for the compound across a panel of 60 cancer cell lines

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