TGF-β / Smad Signaling
- Cat.No. Product Name Information
- A1805 Imatinib Mesylate (STI571) Imatinib mesylate is a tyrosine kinase inhibitor IC50 value of 100 nM, 100 nM, 600 nM for v-Abl, c-kit, PDGFR, respectively .
- A2149 Bosutinib (SKI-606) Bosutinib (SKI-606) is a potent inhibitor of Src and Abl kinases with IC50 of 1.2 nM and 1 nM .
Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively .
SLx-2119(KD-025) is a selective inhibitor of ROCK2 with IC50 of 105 nM .
- A3808 SD-208 SD-208 inhibits the growth inhibition of TGF-β–sensitive CCL64 cells at an EC50 of 0.1 μmol/L
- A3773 ROCK inhibitor ROCK inhibitor (Rho-kinase inhibitor) is useful for Anti-cancer.
- A3771 RKI-1447 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.
- A3754 RepSox RepSox can efficiently replace transgenic Sox2 in the absence of VPA and cMyc, as well as in both embryonic and adult fibroblasts, we chose to further characterize E-616452 and named it RepSox, for Replacement of Sox2.
- A3660 Nilotinib monohydrochloride monohydrate Nilotinib monohydrochloride monohydrate
- A3658 NG25 NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.