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TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. A1805 Imatinib Mesylate (STI571) Imatinib mesylate is a tyrosine kinase inhibitor IC50 value of 100 nM, 100 nM, 600 nM for v-Abl, c-kit, PDGFR, respectively .
  3. A2149 Bosutinib (SKI-606) Bosutinib (SKI-606) is a potent inhibitor of Src and Abl kinases with IC50 of 1.2 nM and 1 nM .
  4. A8232 Nilotinib(AMN-107)

    Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively .

  5. A3825 SLx-2119

    SLx-2119(KD-025) is a selective inhibitor of ROCK2 with IC50 of 105 nM [1].

  6. A3808 SD-208 SD-208 inhibits the growth inhibition of TGF-β–sensitive CCL64 cells at an EC50 of 0.1 μmol/L
  7. A3773 ROCK inhibitor ROCK inhibitor (Rho-kinase inhibitor) is useful for Anti-cancer.
  8. A3771 RKI-1447 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.
  9. A3754 RepSox RepSox can efficiently replace transgenic Sox2 in the absence of VPA and cMyc, as well as in both embryonic and adult fibroblasts, we chose to further characterize E-616452 and named it RepSox, for Replacement of Sox2.
  10. A3660 Nilotinib monohydrochloride monohydrate Nilotinib monohydrochloride monohydrate
  11. A3658 NG25 NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.

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