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TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. B1293 Y-27632 Y-27632 is a specific inhibitor of Rho-associated kinases(ROCK) family with Ki values of 0.22μM and 0.30μM for ROCK1 and ROCK2, respectively.
  3. B1176 Y-39983 dihydrochloride Y-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK .
  4. A8812 PD173955 PD173955 is a potent inhibitor of Bcr-Abl, Src and Yes with IC50 value of 1-2 nM, 300 nM and 175 nM, respectively [1-3].
  5. A8692 PF-431396 PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells.
  6. A8607 PPY A Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively).
  7. A8606 PD 180970 ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells.
  8. A8605 1-Naphthyl PP1 Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl.
  9. A8604 GNF 5 GNF-5 is a potent, selective, non-ATP competitive allosteric inhibitor of Bcr-Abl with IC50 value of 220 nM.
  10. A8603 GNF 2 GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 100 to 300 nM in various cell lines.
  11. A8602 Adaphostin p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro.

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