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Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

product-structure
  1. Cat.No. Product Name Information
  2. A4417 Ivachtin Caspase-3 inhibitor
  3. A8177 PAC-1 Procaspase-3 activator
  4. A4420 PETCM Caspase-3 activator
  5. A8165 Q-VD(OMe)-OPh Pan-caspase inhibitor
  6. A1901 Q-VD-OPh hydrate Cell-permeable, irreversible pan-caspase inhibitor
  7. A8238 VX-765 Caspase-1 inhibitor,potent and selective
  8. A1920 Z-DEVD-FMK Caspase-3 inhibitor
  9. A1921 Z-DQMD-FMK Caspase-3 inhibitor,cell-permeable
  10. A8170 Z-FA-FMK Cysteine proteases inhibitor
  11. B3232 Z-IETD-FMK Caspase-8 inhibitor

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