Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- Cat.No. Product Name Information
- B3233 Z-LEHD-FMK Irreversible Caspase-9 inhibitor.
- A8165 Q-VD(OMe)-OPh Pan-caspase inhibitor
- A8321 Cisplatin Inhibits DNA synthesis,chemotherapy drug
- A8177 PAC-1 Procaspase-3 activator
- A4420 PETCM Caspase-3 activator
- A4016 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable
- A8170 Z-FA-FMK Cysteine proteases inhibitor
- A4417 Ivachtin Caspase-3 inhibitor
- A1930 Apoptosis Inhibitor Associate with caspase-3 inhibition
- A4416 AZ 10417808 Caspase-3 inhibitor,selective non-peptide