Search Site
Home >> Signaling Pathways >> Proteases >> Caspase

Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Biochemicals

  1. Cat.No. Product Name Information
  2. A1901 Q-VD-OPh hydrate Top Seller Cell-permeable, irreversible pan-caspase inhibitor
  3. A1902 Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor
  4. A1920 Z-DEVD-FMK Top Seller Caspase-3 inhibitor
  5. A1925 Caspase-3/7 Inhibitor I Top Seller Caspase-3/7 inhibitor
  6. A9901 Caspase Inhibitor Set I Caspase Inhibitors
  7. A8238 VX-765 Caspase-1 inhibitor,potent and selective
  8. A1923 Z-VEID-FMK Top Seller Caspase-6 inhibitor
  9. A1922 Z-VDVAD-FMK Top Seller Caspase-2 inhibitor
  10. A1921 Z-DQMD-FMK Top Seller Caspase-3 inhibitor,cell-permeable
  11. B3232 Z-IETD-FMK Caspase-8 inhibitor
  12. A8165 Q-VD(OMe)-OPh Top Seller Pan-caspase inhibitor
  13. B3233 Z-LEHD-FMK Irreversible Caspase-9 inhibitor.
  14. A8321 Cisplatin Top Seller Inhibits DNA synthesis,chemotherapy drug
  15. A8177 PAC-1 Top Seller Procaspase-3 activator
  16. A8170 Z-FA-FMK Top Seller Cysteine proteases inhibitor
  17. A4016 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable
  18. A4420 PETCM Caspase-3 activator
  19. A1930 Apoptosis Inhibitor Top Seller Associate with caspase-3 inhibition
  20. A4417 Ivachtin Caspase-3 inhibitor
  21. A4416 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  22. A1904 Boc-D-FMK Pan-caspase inhibitor
  23. A4419 Ac-LEHD-AFC Fluorogenic caspase substrate
  24. A1924 Z-WEHD-FMK Caspase 5 inhibitor,potent,cell-permeable and irreversible
  25. A3424 Gambogic Acid Caspase activator and apoptosis inducer
  26. A4418 Ac-IEPD-AFC Recognition motif for serine protease granzyme B