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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

product-structure
  1. Cat.No. Product Name Information
  2. A8381 BIBR-1048 Thrombin inhibitor
  3. A4058 BIIB021 Hsp90 inhibitor,selective and competitive
  4. A3244 Bivalirudin Trifluoroacetate Reversible thrombin inhibitor
  5. A4400 BMS 299897 γ--secretase inhibitor, potent and orally active
  6. A3253 BMS-626529 HIV-1 attachment inhibitor
  7. A4069 BMS-707035 HIV-I integrase inhibitor,potent and specific
  8. A4022 BMS-708163 (Avagacestat) γ-secretase inhibitor
  9. A3257 BMS-790052 dihydrochloride HCV NS5A inhibitor
  10. A1904 Boc-D-FMK Pan-caspase inhibitor
  11. A3261 Boceprevir HCV protease inhibitor,potent and selective

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