Proteases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
Products for Proteases
- Caspase(29)
- Aminopeptidase(12)
- ACE(13)
- Calpains(13)
- Carboxypeptidase(8)
- Cathepsin(16)
- DPP-4(22)
- Elastase(14)
- Gamma Secretase(31)
- HCV Protease(22)
- HSP(32)
- HIV Integrase(16)
- HIV Protease(16)
- MMP(32)
- NS3/4a protease(6)
- Serine Protease(11)
- Thrombin(18)
- Urokinase(6)
- Cysteine Protease(0)
- Other Proteases(15)
- Tyrosinases(1)
- Cat.No. Product Name Information
-
C3609
(Z-Ala-Ala-Ala-Ala)2Rh110
fluorogenic elastase substrate
-
A4054
17-AAG (KOS953)
Hsp90 inhibitor
-
A2213
17-DMAG (Alvespimycin) HCl
Hsp90 inhibitor
-
C5038
2-cyano-Pyrimidine
cathepsin K inhibitor
-
C3265
2-Guanidinoethylmercaptosuccinic Acid
carboxypeptidase E inhibitor
-
B7734
2-MPPA
glutamate carboxypeptidase II (GCP II) inhibitor
-
A4445
4-Chlorophenylguanidine hydrochloride
Urokinase inhibitor, potent and specific
-
A3126
5-R-Rivaroxaban
Factor Xa (FXa) inhibitor
-
A4418
Ac-IEPD-AFC
Recognition motif for serine protease granzyme B
-
A4419
Ac-LEHD-AFC
Fluorogenic caspase substrate