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PPAR

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

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  1. Cat.No. Product Name Information
  2. B7010 15-deoxy-Δ-12,14-Prostaglandin J2 PPARγ agonist
  3. C5280 3-Thiatetradecanoic Acid activator of PPAR
  4. A8957 AUDA Potent epoxide hydrolase inhibitor/PPARα activator
  5. B6691 BADGE PPARγ antagonist
  6. A3216 Balaglitazone PPAR-γ partial agonist
  7. C3544 BMS 687453 PPARα agonist
  8. C5151 Cetaben unique,PPARα-independent peroxisome proliferator
  9. B6681 Ciglitazone PPARγ agonist
  10. A4306 Ciprofibrate PPARα agonist
  11. B3610 Clofibrate PPAR agonist

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