PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- Cat.No. Product Name Information
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B7010
15-deoxy-Δ-12,14-Prostaglandin J2
PPARγ agonist
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C5280
3-Thiatetradecanoic Acid
activator of PPAR
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A8957
AUDA
Potent epoxide hydrolase inhibitor/PPARα activator
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B6691
BADGE
PPARγ antagonist
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A3216
Balaglitazone
PPAR-γ partial agonist
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C3544
BMS 687453
PPARα agonist
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C5151
Cetaben
unique,PPARα-independent peroxisome proliferator
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B6681
Ciglitazone
PPARγ agonist
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A4306
Ciprofibrate
PPARα agonist
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B3610
Clofibrate
PPAR agonist