Home >> Signaling Pathways >> Metabolism >> IDO

IDO

Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing the oxidative degradation of L-tryptophan in the kynurenine pathway, in which the pyrrole ring of L-tryptophan is cleaved to generate N-formyl-kynurenine. Mature human IDO enzyme is a 45 kDa monomeric protein of 403 amino acids that is encoded by the IDO gene (15 kb with 10 exons). According to X-ray crystallographic analysis, the chemical structure of human IDO enzyme consists of two distinct α-helical domains (one small and one large) and a heme prosthetic group, where the heme is coordinated to the active site by a histidine (His) imidazole as the proximal fifth ligand.

Compare Products

product-structure
  1. Cat.No. Product Name Information
  2. A3483 IDO inhibitor 1 Indoleamine-2,3-dioxygenase inhibitor
  3. C3211 IDO-IN-1 indoleamine-2,3-dioxygenase (IDO) inhibitor
  4. B6036 INCB-024360 potent and selective inhibitor of IDO1
  5. A3493 INCB024360 analogue potent and selective inhibitor of IDO1
  6. B4900 Indoximod (NLG-8189) Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor
  7. A4373 NLG919 Potent IDO pathway inhibitor
  8. C4982 Norharmane inhibitor of indoleamine 2,3-dioxygenase

7 Item(s)

per page

Set Descending Direction