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JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

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Biochemicals

  1. Cat.No. Product Name Information
  2. B1259 (3R,4S)-Tofacitinib Novel inhibitor of JAK3
  3. A3741 Pyridone 6 Pan-JAK inhibitor
  4. A3781 Ruxolitinib phosphate JAK1/JAK2 inhibitor
  5. A3782 Ruxolitinib sulfate JAK inhibitor
  6. A3794 SB1317 CDK,JAK and FLT inhibitor
  7. A3936 WHI-P97 Janus kinase (JAK)-3 inhibitor
  8. A3937 XL019 JAK2 inhibitor,potent and selective
  9. A4510 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
  10. A4511 Cercosporamide Mnk2 and JAK3 inhibitor
  11. A4512 Cucurbitacin I STAT3/JAK2 signaling inhibitor
  12. A4513 Lestaurtinib JAK2/FLT3/TrkA inhibitor
  13. A4515 SD 1008 Inhibitor of JAK2/STAT3 signaling pathway,apoptosis inducer
  14. A4516 TCS 21311 JAK3 inhibitor
  15. A4517 ZM 449829 JAK3 inhibitor
  16. A4514 NSC 33994 Selective JAK2 inhibitor
  17. B1130 GLPG0634 JAK1 inhibitor
  18. B1258 (3S,4R)-Tofacitinib Novel inhibitor of JAK3
  19. B1031 (3S,4S)-Tofacitinib Inhibitor of JAK3
  20. A3515 JANEX-1 JAK3 inhibitor
  21. A3514 JAK2 Inhibitor V, Z3 Jak2 tyrosine kinase inhibitor
  22. A4144 AZ 960 JAKs inhibitor
  23. A4143 CYT387 Top Seller JAK-1/-2 inhibitor,ATP competitive
  24. A4141 Baricitinib (LY3009104, INCB028050) JAK1/JAK2 inhibitor,selective orally bioavailable
  25. A4140 WP1066 Top Seller JAK2/STAT3 inhibitor,cell-permeable
  26. A4138 Tofacitinib (CP-690550,Tasocitinib) Janus kinase inhibitor
  27. A4137 AZD1480 JAK2 inhibitor,ATP-competitive and novel
  28. A4136 TG101348 (SAR302503) Top Seller JAK-2 inhibitor,potent and selective
  29. A3012 Ruxolitinib (INCB018424) Top Seller JAK inhibitor
  30. A4145 TG101209 Top Seller JAK2/3 inhibitor
  31. A4146 CEP-33779 JAK2 inhibitor,highly selective
  32. A3339 CYT387 sulfate salt JAK1/JAK2 inhibitor
  33. A3222 Baricitinib phosphate JAK1/JAK2 inhibitor
  34. A3221 Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator
  35. A4152 BMS-911543 JAK2 inhibitor,selective small molecule
  36. A4151 ZM 39923 HCl JAK3 inhibitor,potent and selective
  37. A4150 WHI-P154 JAK3 inhibitor
  38. A4149 S-Ruxolitinib (INCB018424) JAK1/2 inhibitor,potent and selective
  39. A4147 LY2784544 JAK2 inhibitor,highly potent and selective
  40. A4135 Tofacitinib (CP-690550) Citrate Top Seller Potent JAK inhibitor
  41. A4148 NVP-BSK805 2HCl JAK2 inhibitor
  42. A3675 NVP-BSK805 Top Seller ATP-competitive JAK2 inhibitor
  43. B6116 GLPG0634 analogue JAK1 inhibitor, potent and selective