Home >> Signaling Pathways >> Chromatin/Epigenetics >> PARP

PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

product-structure
  1. Cat.No. Product Name Information
  2. A1877 XAV-939 Tankyrase 1/2 inhibitor

Items 31 to 31 of 31 total

per page
  1. 1
  2. 2
  3. 3
  4. 4

Set Descending Direction