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PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

product-structure
  1. Cat.No. Product Name Information
  2. A4154 Olaparib (AZD2281, Ku-0059436) Potent PARP1/PARP2 inhibitor
  3. A3729 PJ34 PARP-l inhibitor
  4. A4159 PJ34 hydrochloride PARP inhibitor,potent and cell-permeable
  5. A4156 Rucaparib (AG-014699,PF-01367338) Potent PARP inhibitor
  6. A8893 Rucaparib (free base) Potent PARP inhibitor
  7. A8600 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor
  8. A8601 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
  9. A4163 UPF 1069 Selective PARP2 inhibitor
  10. A3958 Veliparib dihydrochloride PARP-1/PARP-2 inhibitor
  11. A4531 WIKI4 Inhibitor of Wnt/ß-Catenin signaling and tankyrase

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