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Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

  1. Cat.No. Product Name Information
  2. A4528 EB 47 Potent PARP-1 inhibitor
  3. A4157 Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered
  4. A4161 INO-1001 Potent PARP inhibitor
  5. A4529 JW 55 PARP domain inhibitor
  6. A8808 ME0328 PARP inhibitor,potent and selective
  7. A3617 MK-4827 PARP-1/-2 inhibitor,potent and selective
  8. B1163 MK-4827 hydrochloride PARP1/PARP2 inhibitor
  9. B3393 MK-4827 Racemate selective inhibitor of PARP1/PARP2
  10. B1164 MK-4827 tosylate PARP1/PARP2 inhibitor
  11. A4530 NU 1025 PARP inhibitor,potent and novel

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