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HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Research Area

product-structure
  1. Cat.No. Product Name Information
  2. B5969 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  3. C4018 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor
  4. B4106 4SC-202 Class I HDAC inhibitor
  5. B5936 ACY-241 Selective and orally active HDAC6 inhibitor
  6. A8176 Apicidin Potent HDAC inhibitor
  7. A4104 AR-42 (OSU-HDAC42) HDAC inhibitor,novel and potent
  8. A4096 Belinostat (PXD101) Hydroxamate-type HDAC inhibitor
  9. B5949 BG45 Novel HDAC3-selective inhibitor
  10. B5968 BML-210(CAY10433) Novel HDAC inhibitor
  11. B4655 BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective

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